Keiichi Tamai Selected Research

Adapalene (Differin)

8/2022	Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry.
2/2020	Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271.
10/2019	Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells.
1/2019	CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma.
1/2016	CD271 regulates the proliferation and motility of hypopharyngeal cancer cells.
1/2013	CD271 defines a stem cell-like population in hypopharyngeal cancer.

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Keiichi Tamai Research Topics

Disease

28	Neoplasms (Cancer) 08/2022 - 01/2013
4	Neoplasm Metastasis (Metastasis) 01/2021 - 09/2016
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/2022 - 01/2019
3	Cholangiocarcinoma 01/2021 - 06/2014
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 06/2013
3	Hypopharyngeal Neoplasms 10/2019 - 01/2013
3	Stomach Neoplasms (Stomach Cancer) 05/2017 - 01/2013
2	Lung Neoplasms (Lung Cancer) 03/2019 - 07/2018
2	Adenocarcinoma 01/2019 - 03/2018
2	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 03/2017 - 05/2016
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 01/2011
2	Fibrosis (Cirrhosis) 01/2011 - 12/2009
2	Liver Diseases (Liver Disease) 08/2010 - 02/2006
2	Infections 07/2010 - 06/2006
1	Esophageal Neoplasms (Esophageal Cancer) 08/2022
1	Inflammation (Inflammations) 05/2022
1	Weight Loss (Weight Reduction) 05/2022
1	Testicular Neoplasms (Testicular Cancer) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 11/2021
1	Carcinoma (Carcinomatosis) 04/2020
1	Melanoma (Melanoma, Malignant) 10/2019
1	Squamous Cell Carcinoma of Head and Neck 01/2019
1	Colorectal Neoplasms (Colorectal Cancer) 04/2018
1	Colitis 04/2018
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2018
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Lymphoma (Lymphomas) 03/2017
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2017
1	Carcinogenesis 02/2015
1	Parkinson Disease (Parkinson's Disease) 01/2011
1	Body Weight (Weight, Body) 08/2010
1	Coronary Artery Disease (Coronary Atherosclerosis) 08/2010

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 08/2022 - 02/2006
6	Adapalene (Differin)FDA LinkGeneric 08/2022 - 01/2013
3	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 08/2022 - 01/2016
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 07/2010
3	Long Noncoding RNAIBA 01/2018 - 01/2013
3	RNA (Ribonucleic Acid)IBA 01/2018 - 01/2009
2	Monoclonal AntibodiesIBA 08/2022 - 10/2019
2	Glycoproteins (Glycoprotein)IBA 08/2022 - 04/2020
2	CytokinesIBA 05/2022 - 01/2021
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2022 - 01/2011
2	alectinibIBA 01/2021 - 03/2019
2	Carrier Proteins (Binding Protein)IBA 12/2020 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 10/2019 - 01/2013
2	PeriostinIBA 07/2018 - 04/2018
2	Pyruvate KinaseIBA 03/2018 - 05/2017
2	Biological ProductsIBA 03/2018 - 06/2013
2	Amino Acids FDA Link 01/2011 - 12/2009
2	Alanine Transaminase (SGPT)IBA 08/2010 - 07/2010
1	ErbB Receptors (EGF Receptor)IBA 08/2022
1	Tamoxifen FDA LinkGeneric 05/2022
1	CollagenIBA 12/2021
1	involucrinIBA 12/2021
1	matrigelIBA 12/2021
1	Circulating Tumor DNAIBA 11/2021
1	Formaldehyde (Formol)FDA Link 03/2021
1	ParaffinIBA 03/2021
1	nanolucIBA 01/2021
1	lorlatinibIBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 01/2021
1	bis(4-methylumbelliferyl)pyrophosphateIBA 01/2021
1	entrectinibIBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	gilteritinibIBA 01/2021
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2021
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 12/2020
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 12/2020
1	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 04/2020
1	Small Interfering RNA (siRNA)IBA 04/2020
1	AntibodiesIBA 02/2020
1	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 10/2019
1	IntegrinsIBA 04/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 03/2018
1	Pyruvic Acid (Pyruvate)IBA 03/2018
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2018
1	Protein Isoforms (Isoforms)IBA 05/2017
1	Carbonic Anhydrase IXIBA 03/2017
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 03/2017
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017
1	Insulin (Novolin)FDA Link 01/2017
1	Semaphorins (Semaphorin)IBA 09/2016
1	MK 2206IBA 05/2016
1	MicroRNAs (MicroRNA)IBA 02/2015
1	LigandsIBA 06/2014
1	Untranslated RNA (Noncoding RNA)IBA 06/2013
1	Matrix Metalloproteinases (MMPs)IBA 01/2013
1	SynucleinsIBA 01/2011
1	Amyloid (Amyloid Fibrils)IBA 01/2011
1	Messenger RNA (mRNA)IBA 01/2011
1	Glutamic Acid (Glutamate)FDA Link 01/2011
1	Cystine (L-Cystine)IBA 01/2011
1	Triglycerides (Triacylglycerol)IBA 08/2010
1	Nonesterified Fatty Acids (NEFA)IBA 08/2010

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 11/2021 - 01/2021
2	Therapeutics 01/2021 - 12/2020
1	Euthanasia (Mercy Killing) 05/2022
1	Heterologous Transplantation (Xenotransplantation) 05/2016
1	Transplantation 05/2016